Professor

성지혜

Jihye Seong

jihye.seong@snu.ac.kr

Education

Ph.D. in Neuroscience (2012)
University of Illinois at Urbana-Champaign
Advisor: Prof. Peter Yingxiao Wang
M.S. in Pharmaceutical Science (2005)
Seoul National University College of Pharmacy
Advisor: Prof. Chong-Kook Kim
B.S. in Pharmacy (2003)
Seoul National University College of Pharmacy

Postdoctoral Research

Stanford University College of Medicine
Advisor: Prof. Michael Z. Lin
University of Illinois at Urbana-Champaign
Advisor: Prof. Ning Wang

Professional Positions

Professor (2023 – Present)
Seoul National University College of Medicine
Department of Biological Sciences
Principal Investigator (2014 – 2023)
Korea Institute of Science and Technology (KIST)
Brain Science Institute

Selected Publications

Journal of Neuroscience (2025) Optogenetic control of dopamine receptor 2 reveals a novel aspect of dopaminergic neurotransmission in motor function, 45(1): e1473242024 pdf
Small Methods (2024) Novel FRET-based immunological synapse biosensor for the prediction of Chimeric Antigen Receptor-T cell function, 9(3): e2401016 pdf
Sensors and Actuators B: Chemical (2022) Combinatorial effects of RhoA and Cdc42 on the actin cytoskeleton revealed by photoswitchable GEFs, 369:132316 pdf
Acta Neuropathologica (2022) Decreased FAK activity and focal adhesion dynamics impair proper neurite formation of medium spiny neurons in Huntington’s disease, 144(3):521-536 pdf
Cell Reports (2022) Optical regulation of endogenous RhoA reveals switching of cellular responses by signal amplitude, 40(2):111080 pdf
Progress in Neurobiology (2022) Differential receptor crosstalk in the DRD1-DRD2 heterodimer upon phasic and tonic dopamine signals, 213:102266 pdf
Annual Review of Biochemistry (2021) Optobiochemistry: Genetically encoded optical control of protein activity by light, 90:475-501 pdf
Sensors (2021) Genetically encoded biosensors based on fluorescent proteins, 21(3), 795 pdf
Analytical Chemistry (2021) Spatiotemporal kinetics of GPCR activity and function during endosomal trafficking pathway, 93(4):2010-2017 pdf
ACS Sensors (2020) Visualization of autophagy progression by Red-Green-Blue autophagy sensor, 5(12):3850-3861 pdf
Nature Communications (2017) Engineered Proteins with Sensing and Activating Modules for Automated Reprogramming of Cellular Functions, 8(1):477 pdf
Nature Communications (2014) Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression, 5:4619 pdf
PNAS (2013) Distinct biophysical mechanisms of FAK mechanoactivation by different extracellular matrix proteins, 110(48):19372-7 pdf
Nature Communications (2013) N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signaling pathways, 4:1589 pdf
Nature Communications (2011) Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer, 2:406 pdf
Chemistry & Biology (2009) Visualization of Src activity at different compartments of the plasma membrane by FRET imaging, 16(1): 48-57 pdf
J Gene Med (2006) Polyethylenimine-based antisense oligodeoxynucleotides of IL-4 suppress the production of IL-4 in a murine model of airway inflammation, 8(3): 314-2 pdf