Our laboratory is developing fluorescent/luminescent molecular biosensors to investigate dynamic protein interactions and cellular functions. Utilizing these biosensors and live-cell imaging techniques, we are elucidating the molecular mechanisms of cellular functions and dysfunctions. In particular, we are studying G protein-coupled receptors (GPCRs), including neurotransmitter receptors. We are also investigating chimeric antigen receptors (CARs) for cell therapy.
Our laboratory is developing optogenetic/chemogenetic actuators that can selectively regulate protein activity and cellular functions with spatiotemporal precision. For example, we develop photosensitive GPCRs, which can activate specific neurotransmitter receptors to investigate the function of neural circuits in the brain. We are also designing effective therapeutic proteins for cell therapy, including CARs.