Kim HJ, Lee HN, Kim S, Hyeon SJ, Inn K-S, Ryu H, Seong J* Submitted
Kim HB#, Park G#, Shin HG, Kwon D, Kim HJ, Baek I-Y, Nam M-H, Cho I-J, Kim J*, Seong J* (2024) Optogenetic control of dopamine receptor 2 reveals a novel aspect of dopaminergic neurotransmission in motor function. Journal of Neuroscience 45(1):e1473242024
Kim HB, Lee H, Seong J* (2024) Unveiling the Complexity of G Protein-Coupled Receptor Heteromers: Advances in Live Cell Imaging Technologies and Biochemical Methods. Med-X 2:16
Lee HN, Lee S, Hong J, Yoo H, Jeong J, Kim Y-W, Shin HM, Jang M*, Lee C-H*, Kim H-R*, Seong J* (2024) Novel FRET-based Immunological Synapse Biosensor for the Prediction of Chimeric Antigen Receptor-T cell Function. Small Methods 9(3):e2401016 [한빛사논문]
Lee HN, Lee SE, Inn K-S, Seong J* (2024) Optical sensing and control of T cell signaling pathways. Frontiers in Physiology, 14:1321996
Yeon N-R, Cho JS, Yoo H-S, Jeon SH, Yi C-M, Jung M-J, Lee Y-S, Shin E-B, Kim N, Kim H, Seong J, Kim N-J, Lee JK, Inn K-S (2024) Dextran sodium sulfate (DSS)-induced colitis is alleviated in mice after administration of flavone-derived NRF2-activating molecules. Life Sciences, 340:122424
Jeong S, Kang HW, Kim SH, Hong G-S, Nam M-H, Seong J, Yoon E-S, Cho I-J, Chung S, Bang S, Kim HN, Choi N (2023) Integration of reconfigurable microchannels into aligned three-dimensional neural networks for spatially controllable neuromodulation. Science Advances, 9(10):eadf0925
Seong J* Wang Y* (2022) Editorial: Visualization of molecular dynamics in live cells by flourescent protein-based biosensors Front Cell Dev Biol 10:1054774
Kim HB, Baek I-Y, Seong J* (2022) Genetically encoded fluorescent biosensors for GPCR research Front Cell Dev Biol 10:1007893
Ryu H, Lee HN, Ju J, Park J-B, Oh E, Lin MZ*, Seong J* (2022) Combinatorial effects of RhoA and Cdc42 on the actin cytoskeleton revealed by photoswitchable GEFs. Sensors and Actuators B: Chemical 369:132316
Lee HN#, Hyeon SJ#, Kim HJ, Sim KM, Kim Y, Ju J, Lee J, Wang Y, Ryu H*, Seong J* (2022) Decreased FAK activity and focal adhesion dynamics impair proper neurite formation of medium spiny neurons in Huntington’s disease Acta Neuropathologica 144(3):521-536 [한빛사논문]
Ju J#, Lee HN#, Ning L, Ryu H, Zhou XX, Chun H, Lee YW, Lee-Richerson AI, Jeong C, Lin MZ*, Seong J* (2022) Optical regulation of endogenous RhoA reveals switching of cellular responses by signal amplitude. Cell Reports 40(2):111080 [한빛사논문]
Kim HB, Nam MH, Jeong S, Lee H, Oh SJ, Kim J, Choi N, Seong J* (2022) Visualization of differential GPCR crosstalk in DRD1-DRD2 heterodimer upon different dopamine levels. Progress in Neurobiology 213:102266 [한빛사논문]
Kim D, Lee J, Kwag R, Kim HB, Oh H, Moon B, Kim HJ, Seong J, Jeon B, Kang T, Choo H (2021) N-(Biphenyl-3-ylmethyl)ethanamines as G protein-biased agonists of 5-HT7R. Bull Korean Chem Soc. 43(1), 73-77
Lee SY, Choi S-H, Lee MS, Kurmashev A, Lee HN, Ko Y-G, Seong J, Kang JH, Kim H, Retraction fibers produced by fibronectin-integrin a5ß1 interaction promote motility of brain tumor cells. FASEB J. 35(10):e21906.
Seong J* and Lin MZ* (2021) Optobiochemistry: Genetically encoded control of protein activity by light, Annual Review of Biochemistry [한빛사논문], 90:475–501 Full text link
Kim HJ, Seong J* (2021) Fluorescent protein-based autophagy biosensors, Materials,14(11): 3019
Son SH, Do JM, Yoo JN, Lee HW, Kim NK, Yoo HS, Gee MS, Kim JH, Seong J, Inn KS, Seo MD, Lee JK, Kim NJ (2021) Identification of ortho catechol-containing isoflavone as a privileged scaffold that directly prevents the aggregation of both amyloid β plaques and tau-mediated neurofibrillary tangles and its in vivo evaluation, Bioorganic Chemistry 113:105022
Hwang YJ, Hyeon SJ, Kim Y, Lim S, Lee MY, Kim JE, Londhe A, Kim Y, Pae AN, Cho YS, Seong J, Seo H, Kim YK, Choo HY, Ryu H, Min SJ (2021) Modulation of SETDB1 activity by APQ ameliorates heterochromatin condensation, motor function, and neuropathology in a Huntington’s disease mouse model, J Enzyme Inhib Med Chem, 36(1):856-868
Kim HB, Ju J, Lee HN, Chun H, Seong J* (2021) Genetically encoded biosensors based on fluorescent proteins, Sensors, 21(3), 795.
Kim HB, Lee HN, Choi J*, Seong J* (2021) Spatiotemporal kinetics of GPCR activity and function during endosomal trafficking pathway, Analytical Chemistry, 93(4):2010-2017.
Kim JG, Mahmud S, Min JK, Lee Y-B, Kim HB, Kang D-C, Park H-S, Seong J, Park J-B (2021) RhoA GTPase phosphorylated at tyrosine 42 by Src kinase binds to β-catenin and contributes transcriptional regulation of vimentin upon Wnt3A, Redox Biology, 40:101842.
Kim HJ, Kim HB, Choi J, Inn K-S *, Seong J* (2020) Visualization of autophagy progression by Red-Green-Blue autophagy sensor, ACS Sensors (Cover article), 5(12):3850-3861.
Lee HN, Sim KM, Ju J, Kim HB, Pae AN, Park J-B, Ryu H, Seong J* (2019) Aβ modulates actin cytoskeleton via SHIP2-mediated phosphoinositide metabolism, Scientific Reports. 9(1):15557
Kim TJ, Lei L, Seong J, Suh JS, Jang YK, Jung SH, Sun J, Kim DH, and Wang Y (2019) Matrix rigidity-dependent regulation of Ca2+ at plasma membrane microdomains by FAK visualized by fluorescence resonance energy transfer, Advanced Science, 6(4):1801290
Sawant VS, Park H, Paek SY, Lee J, Choi JW, Park KD, Choi KI, Seong J, Lee S and Choo H (2019) Benzoxazoles as Selective Monoamine Oxidase B (MAO-B) Inhibitors, Bull Korean Chem Soc.
Lee NR, Ban J, Lee NJ, Yi CM, Choi JY, Kim HB, Lee JK, Seong J, Cho NH, Jung JU, Inn KS (2018) Activation of RIG-I-Mediated Antiviral Signaling Triggers Autophagy Through the MAVS-TRAF6-Beclin-1 Signaling Axis. Front Immunol. 9:2096.
Lim JW, Kim SK, Choi SY, Kim DH, Gadhe CG, Lee HN, Kim HJ, Kim J, Cho SJ, Hwang H, Seong J, Jeong KS, Lee JY, Lim SM, Lee JW, Pae AN (2018) Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer’s disease, Eur J Med Chem. 3;157:405-422
Kim Y, Kim H, Lee J, Lee JK, Min SJ, Seong J, Rhim H, Tae J, Lee HJ, Choo H (2018) Discovery of β-Arrestin Biased Ligands of 5-HT7R, J Med Chem. 23;61(16):7218-7233
Park I, Hwang YJ, Kim T, Viswanath ANI, Londhe AM, Jung SY, Sim KM, Min SJ, Lee JE, Seong J, Kim YK, No KT, Ryu H, Pae AN (2017) In silico probing and biological evaluation of SETDB1/ESET-targeted novel compounds that reduce tri-methylated histone H3K9 (H3K9me3) level, J Comput Aided Mol Des. 31(10):877-889
Sun J, Lei L, Tsai C-M, Wang Y, Shi Y, Ouyang M, Lu S, Seong J, Kim T-J, Wang P, Huang M, Xu X, Nizet V, Chien S, Wang Y (2017) Engineered Proteins with Sensing and Activating Modules for Automated Reprogramming of Cellular Functions, Nature Communications. 8(1):477
Yi CM, Yu J, Kim HB, Lee NR, Kim SW, Lee NJ, Lee J, Seong J*, Kim NJ*, Inn KS* (2017) Identification of actin as a direct proteomic target of berberine using an affinity-based chemical probe and elucidation of its modulatory role in actin assembly, Chem Commun. 53(52):7045-7047 DOI: 10.1039/c7cc02789c
Seong J*, Huang M, Sim KM, Kim HB, Wang Y* (2017) FRET-based Visualization of PDGF Receptor Activation at Membrane Microdomains, Scientific Reports. 7: 1593
Tan Y, Wood AR, Jia Q, Zhou W, Luo J, Yang F, Chen J, Chen J, Sun J, Seong J, Tajik A, Singh R, Wang N (2017) Soft matrices downregulate FAK activity to promote growth of tumor-repopulating cells, Biochem Biophys Res Commun. 483 (2017) 456e462
Cho NC, Seo SH, Kim D, Shin JS, Ju J, Seong J, Seo SH, Lee I, Lee KT, Kim YK, No KT, Pae AN (2016) Pharmacophore-based virtual screening, biological evaluation and binding mode analysis of a novel protease-activated receptor 2 antagonist, J Comput Aided Mol Des. 30: 625
Lee H, Oh WC, Seong J*, Kim J* (2016) Advanced Fluorescence Protein-Based Synapse-Detectors. Front. Synaptic Neurosci. 8:16
Wu Y, Zhang K, Seong J, Fan J, Chien S, Wang Y, Lu S (2016) In-situ coupling between kinase activities and protein dynamics within single focal adhesions, Scientific Reports. 7;6:29377
Chowdhury F, Li ITS, Leslie BJ, Doganay S, Singh R, Wang X, Seong J, Lee S-H, Park S, Wang N, Ha T (2015) Single molecular force across single integrins dictates cell spreading, Integrative Biology. 7(10):1265-71
Zhuo Y, Qian T, Wu Y, Seong J, Gong Y, Ma H, Wang Y, Lu S (2015) Subcellular and Dynamic Coordination between Src Activity and Cell Protrusion under Microenvironment modulations, Scientific Reports. 11;5:12963
Seong J* (2015). Lipid rafts signaling detected by FRET-based molecular biosensors. J Korean Soc Appl Biol Chem. 58: 629
Kim TJ, Joo C, Seong J, Vafabakhsh R, Botvinick EL, Berns MW, Palmer AE, Wang N, Ha T, Jakobsson E, Sun J, Wang Y (2015). Distinct mechanisms regulating mechanical force-induced Ca2+ signals at the plasma membrane and the ER in human MSCs. Elife. 4:e04876.
Tan Y, Tajik A, Chen J, Jia Q, Chowdhury F, Wang L, Chen J, Zhang S, Hong Y, Yi H, Wu DC, Zhang Y, Wei F, Poh YC, Seong J, Singh R, Lin LJ, Doğanay S, Li Y, Jia H, Ha T, Wang Y, Huang B, Wang N (2014). Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression. Nature Communications. 5:4619.
Lu S, Seong J, Wang Y, Chang SC, Eichorst JP, Ouyang M, Li JY, Chien S, Wang Y (2014). Decipher the dynamic coordination between enzymatic activity and structural modulation at focal adhesions in living cells. Scientific Reports. 4:5756.
Seong J, Tajik A, Sun J, Guan J-L, Humphries MJ, Craig SE, Shekaran A, Garcia AJ, Wang N, Wang Y (2013). Distinct Mechanism of FAK Mechanoactivation by Different Extracellular Matrix Proteins. PNAS (Selected by F1000Prime Biology) [한빛사논문] 110(48):19372-7.
Seong J, Wang N, Wang Y (2013). Mechanobiology at focal adhesions: physiology to cancer development, J Cell Mol Med. 17(5):597-604.
Ouyang M, Lu S, Kim T, Chen C-E, Seong J, Leckband DE, Wang F, Reynolds A, Schwartz MA, Wang Y (2013). N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signaling pathways, Nature Communications. 4:1589.
Seong J, Ouyang M, Kim T, Sun J, Wen P-C, Lu S, Llewellyn NM, Schlaepfer DD, Guan J-L, Chien S, Wang Y (2011). Detect FAK Activations at Membrane Microdomains by FRET, Nature Communications [한빛사논문] 2:406.
Lu S, Kim T, Chen C-E, Ouyang M, Seong J, Liao X, Wang Y (2011). Computational Analysis of the Spatiotemporal Coordination of Polarized PI3K and Rac1 Activities in Micro-patterned Live Cells, PLoS ONE. 6(6):e21293.
Seong J, Lu S, Wang Y (2011). Live Cell Imaging of Src/FAK Signaling by FRET, Cell Mol Bioeng. 4(2):138-147.
Seong J, Lu S, Ouyang M, Huang H, Zhang J, Frame MC, Wang Y (2009). Visualization of Src activity at different compartments of the plasma membrane by FRET imaging, Chemistry and Biology (Cover article). 16(1):48-57.
Kim TJ, Seong J, Ouyang M, Sun J, Lu S, Hong JP, Wang N, Wang Y (2009). Substrate rigidity regulates Ca2+ oscillation via RhoA pathway in stem cells, J Cell Physiol. 218(2):285-93.
Lu S, Ouyang M, Seong J, Zhang J, Chien S, Wang Y (2008). The spatiotemporal pattern of Src activation at lipid rafts revealed by diffusion-corrected FRET imaging, PLoS Comput Biol. 4(7):e1000127.
Ouyang M, Lu S, Li X-Y, Xu J, Seong J, Giepmans B, Shyy Y-J, Weiss SJ, Wang Y (2008). Directional MT1-MMP Activity in Live Cells Visualized by a FRET Biosensor, J Biol Chem. 283(25):17740-8.
Seong JH, Lee KM, Kim ST, Jin SE, and Kim CK (2006). Polyethylenimine-based antisense oligodeoxynucleotides of IL-4 suppress the production of IL-4 in a murine model of airway inflammation, J Gene Med. 8(3):314-23.